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Copper and iron interactions with angiotensin-converting enzyme inhibitors. A study by fast-atom bombardment tandem mass spectrometry

✍ Scribed by Cristina M. L. Silva; M. Filomena Duarte; M. Lourdes Mira; M. Helena Florêncio; Kees Versluis; Albert J. R. Heck

Publisher
John Wiley and Sons
Year
1999
Tongue
English
Weight
64 KB
Volume
13
Category
Article
ISSN
0951-4198

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✦ Synopsis

Fast atom bombardment, combined with high-energy collision-induced tandem mass spectrometry, has been used to investigate gas-phase metal-ion interactions with captopril, enalaprilat and lisinopril, all angiotensin-converting enzyme inhibitors.

Suggestions for the location of metal-binding sites are presented. For captopril, metal binding occurs most likely at both the sulphur and the nitrogen atom. For enalaprilat and lisinopril, binding preferably occurs at the amine nitrogen.

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