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Non-covalent complexes of nucleosides and nucleobases with β-cyclodextrin: a study by fast atom bombardment mass spectrometry and collision-induced dissociation

✍ Scribed by Madhusudanan, K. P.; Katti, S. B.; Dwivedi, A. K.

Publisher
John Wiley and Sons
Year
1998
Tongue
English
Weight
255 KB
Volume
33
Category
Article
ISSN
1076-5174

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✦ Synopsis

Naturally occurring nucleosides and nucleobases form inclusion complexes with b-cyclodextrin. These host-guest complexes could be detected by fast atom bombardment mass spectrometry. The collision-induced dissociation spectra of the protonated complexes showed mainly ions related to the guest molecules. However, deoxyribonucleoside complexes also exhibited facile elimination of the sugar moiety, whereas this fragmentation was absent in ribonucleoside complexes. The deprotonated inclusion complexes underwent collision-induced dissociation to give mainly the deprotonated host molecule. It appears, therefore, that the protonated complexes have protonated guests inside the cavity of the neutral host and the deprotonated complexes have neutral guests in the cavity of the deprotonated host.

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