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Electrophoretic and kinetic studies of human erythrocytes deficient in pyrimidine 5'-nucleotidase

โœ Scribed by Ishida Yoji; Miwa Shiro; Miura Yukari; Kibe Atsuko


Book ID
115822910
Publisher
Elsevier Science
Year
1980
Tongue
English
Weight
544 KB
Volume
108
Category
Article
ISSN
0009-8981

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๐Ÿ“œ SIMILAR VOLUMES


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โœ Raymonde Rosa; Henri Rochant; Bernard Dreyfus; Colette Valentin; Jean Rosa ๐Ÿ“‚ Article ๐Ÿ“… 1977 ๐Ÿ› Springer ๐ŸŒ English โš– 418 KB

A new case of a defect in red cell pyrimidine 5'-nucleotide (P5N) activity was found in a large family from Guadeloupe in the West Indies. The propositus presented a characteristic hemolytic anemia with red cell basophilic stippling, an increased GSH level, and a shift of the peak in absorbance of n

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The mutant enzyme of a patient with hereditary pyrimidine 5'-nucleotidase deficiency was analyzed biochemically. Partially purified by DEAE-Sephadex and concentrated by ultrafiltration, the enzyme had a high Km for the substrate uridine monophosphate. Utilization of the substrate cytidine monophosph