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Electronic structures of cephalosporins and penicillins. 5. Optical activity of the penicillin nucleus chromophores

โœ Scribed by Boyd, Donald B.; Yeh, Chin-Yah; Richardson, F. S.

Book ID
126979217
Publisher
American Chemical Society
Year
1976
Tongue
English
Weight
1016 KB
Volume
98
Category
Article
ISSN
0002-7863

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A series of 6-(carboxymethylene)penicillinates and 7-(carboxymethylene)cephalosporanates were synthesized and evaluated as inhibitors of one type A and two type C p-lactamases. Disodium 6-(carboxymethylene)penicillinate sulfone (15) showed broad spectrum activity. A kinetic analysis demonstrated tha