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Electroencephalographic signs of ethanol tolerance and physical dependence in the cat

✍ Scribed by R.G Perrin; H Kalant; K.E Livingston


Book ID
115862622
Publisher
Elsevier Science
Year
1975
Tongue
English
Weight
457 KB
Volume
39
Category
Article
ISSN
0013-4694

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Dogs were treated with clorazepate, which is known to be completely metabolized to desmethyldiazepam. 2 mgikg t.i.d. were given orally for 5-6 weeks, a dose regimen providing plasma concentrations of desmethyldiazepam in the range known to be therapeutic in man. The rate of development of tolerance