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Dissociation of tolerance and physical dependence after ethanol/chlordiazepoxide intake

✍ Scribed by Arthur W.K. Chan; Donna L. Schanley; Florence W. Leong; Diane Casbeer


Book ID
113218972
Publisher
Elsevier Science
Year
1982
Tongue
English
Weight
578 KB
Volume
17
Category
Article
ISSN
0091-3057

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Rats were treated by intragastric intubation of a 20 % ethanol solution in doses of 9-15 g/kg in 3-5 fractions for 1-7 days. Both tolerance and physical dependence were demonstrated after this treatment with the maximum tolerable doses to only a few days. Tolerance was assessed by signs of severity