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Daily dose of ethanol and the development and decay of acute and chronic tolerance and physical dependence in rats

โœ Scribed by Larissa A. Pohorecky; Patricia Roberts

Book ID
113224804
Publisher
Elsevier Science
Year
1992
Tongue
English
Weight
891 KB
Volume
42
Category
Article
ISSN
0091-3057

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Temporal relationship of the induction o
Temporal relationship of the induction of tolerance and physical dependence after continuous intoxication with maximum tolerable doses of ethanol in rats
โœ Edward Majchrowicz; Walter A. Hunt ๐Ÿ“‚ Article ๐Ÿ“… 1976 ๐Ÿ› Springer ๐ŸŒ English โš– 576 KB

Rats were treated by intragastric intubation of a 20 % ethanol solution in doses of 9-15 g/kg in 3-5 fractions for 1-7 days. Both tolerance and physical dependence were demonstrated after this treatment with the maximum tolerable doses to only a few days. Tolerance was assessed by signs of severity