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Electrochemical Oxidation of 2-Substituted Piperidines as a Key Step Towards the Synthesis of Hydroxylated γ-Amino Acids.

✍ Scribed by Kerstin Bodmann; Thorsten Bug; Sabine Steinbeisser; Reinhard Kreuder; Oliver Reiser


Publisher
John Wiley and Sons
Year
2006
Weight
30 KB
Volume
37
Category
Article
ISSN
0931-7597

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✦ Synopsis


Abstract

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## Abstract A facile, convenient, and one‐pot multi‐step synthesis of substituted piperidin‐2‐ones from the __Baylis__–__Hillman__ alcohols derived from various aldehydes and acrylonitrile, involving __Johnson__–__Claisen__ rearrangement, reduction of an __α__,__β__‐unsaturated nitrile moiety into