The Baylis–Hillman Adducts as Valuable Source for One-Pot Multi-Step Synthesis: A Facile Synthesis of Substituted Piperidin-2-ones

✍ Scribed by Deevi Basavaiah; Raju Jannapu Reddy; Dandamudi V. Lenin

• Publisher: John Wiley and Sons
• Year: 2010
• Tongue: German
• Weight: 176 KB
• Volume: 93
• Category: Article
• ISSN: 0018-019X
• DOI: 10.1002/hlca.200900352

✦ Synopsis

Abstract

A facile, convenient, and one‐pot multi‐step synthesis of substituted piperidin‐2‐ones from the Baylis–Hillman alcohols derived from various aldehydes and acrylonitrile, involving Johnson–Claisen rearrangement, reduction of an α,β‐unsaturated nitrile moiety into the saturated amine‐skeleton, followed by cyclization, in an operationally simple procedure, is described.