✦ LIBER ✦

Electrochemical Behaviour of the Anticancer Dacarbazine-Cu2+ Complex and Its Analytical Applications

✍ Scribed by Yassien M. Temerk; Moustafa M. Kamal; Mohamed S. Ibrahim; Hossieny S. M. Ibrahim; Wolfgang Schuhmann

Publisher: John Wiley and Sons
Year: 2011
Tongue: English
Weight: 251 KB
Volume: 23
Category: Article
ISSN: 1040-0397
DOI: 10.1002/elan.201100038

No coin nor oath required. For personal study only.

✦ Synopsis

Abstract

Electrochemical reduction of the dacarbazine‐Cu^2+^ complex was investigated using cyclic voltammetry and square wave voltammetry at a hanging mercury drop electrode. The reduction of the dacarbazine‐Cu^2+^ complex is irreversible. A reduction mechanism is proposed comprising a one‐electron reduction of the Cu^2+^ directly within the complex. The sharp peak of the adsorbed dacarbazine‐Cu^2+^ complex associated with an effective interfacial accumulation facilitates the determination of the anticancer drug dacarbazine in pharmaceutical formulations and biological fluids. Detection limits for dacarbazine of 6.12×10^−10^ M, 1.57×10^−10^ M and 1.97×10^−9^ M were achieved for the determination of the drug in vial, human urine and serum, respectively.

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