✦ LIBER ✦

The first example of MEEKC-ICP-MS coupling and its application for the analysis of anticancer platinum complexes

✍ Scribed by Anna K. Bytzek; Michael R. Reithofer; Markus Galanski; Michael Groessl; Bernhard K. Keppler; Christian G. Hartinger

Publisher: John Wiley and Sons
Year: 2010
Tongue: English
Weight: 261 KB
Volume: 31
Category: Article
ISSN: 0173-0835
DOI: 10.1002/elps.200900522

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✦ Synopsis

Abstract

MEEKC is a powerful electrodriven separation technique with many applications in different disciplines, including medicinal chemistry; however, up to now the coupling to highly sensitive and selective MS detectors was limited due to the ion suppressive effect of the commonly used surfactant SDS. Herein, the first example of the coupling of MEEKC to ICP‐MS is presented and an MEEKC method for the separation of Pt(II) and Pt(IV) anticancer drugs and drug candidates was developed. Different compositions of microemulsions were evaluated and the data were compared with those collected with standard ultraviolet/visible (UV/vis) spectroscopy detection. The MEEKC‐ICP‐MS system was found to be more sensitive than MEEKC‐UV/vis and the analysis of UV/vis silent compounds is now achievable. The migration behavior of the Pt(II) and Pt(IV) compounds under investigation is correlated to their different chemical structures.

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