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Electrocatalytic tandem Knoevenagel–Michael addition of barbituric acids to isatins: Facile and efficient way to substituted 5,5′-(2-oxo-2,3-dihydro-1H-indole-3,3-diyl)bis(pyrimidine-2,4,6-(1H,3H,5H)-trione) scaffold

✍ Scribed by Michail N. Elinson; Valentina M. Merkulova; Alexey I. Ilovaisky; Fructuoso Barba; Belen Batanero


Book ID
113596244
Publisher
Elsevier Science
Year
2011
Tongue
English
Weight
269 KB
Volume
56
Category
Article
ISSN
0013-4686

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Cascade assembly of N,N′-dialkylbarbitur
✍ Michail N. Elinson; Anatolii N. Vereshchagin; Nikita O. Stepanov; Pavel A. Belya 📂 Article 📅 2010 🏛 Elsevier Science 🌐 French ⚖ 249 KB

Cascade assembly of N,N 0 -dialkylbarbituric acids and aldehydes in the presence of bromine leads to the selective and efficient formation of substituted 1,5-dihydro-2H,2 0 H-spiro(furo[2,3-d]pyrimidine-6,5 0pyrimidine)-2,2 0 ,4,4 0 ,6 0 -(1 0 H,3H,3 0 H)-pentones in 70-88% yields via a complex casc

ChemInform Abstract: Cascade Assembly of
✍ Michail N. Elinson; Anatolii N. Vereshchagin; Nikita O. Stepanov; Pavel A. Belya 📂 Article 📅 2011 🏛 John Wiley and Sons ⚖ 30 KB 👁 2 views

## Abstract Reaction of barbituric acid (I) with aromatic aldehydes is investigated in the presence of bromine under 2 different sets of reaction conditions.