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Cascade Assembling of Isatins and Barbituric Acids: Facile and Efficient Way to 2′′ H -Dispiro[indole-3,5′-furo[2,3- d ]pyrimidine-6′,5′′-pyrimidine]-2,2′,2′′,4′,4′′,6′′-(1 H ,1′ H ,1′′ H ,3′ H ,3′′ H )-hexone Scaffold

✍ Scribed by Elinson, Michail N.; Merkulova, Valentina M.; Ilovaisky, Alexey I.; Nikishin, Gennady I.


Book ID
120915180
Publisher
Journal of Heterocyclic Chemistry
Year
2013
Tongue
English
Weight
375 KB
Category
Article
ISSN
0022-152X

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Cascade assembly of N,N′-dialkylbarbitur
✍ Michail N. Elinson; Anatolii N. Vereshchagin; Nikita O. Stepanov; Pavel A. Belya 📂 Article 📅 2010 🏛 Elsevier Science 🌐 French ⚖ 249 KB

Cascade assembly of N,N 0 -dialkylbarbituric acids and aldehydes in the presence of bromine leads to the selective and efficient formation of substituted 1,5-dihydro-2H,2 0 H-spiro(furo[2,3-d]pyrimidine-6,5 0pyrimidine)-2,2 0 ,4,4 0 ,6 0 -(1 0 H,3H,3 0 H)-pentones in 70-88% yields via a complex casc