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Efficient Synthesis of Trisubstituted Pyrazoles and Isoxazoles Using a Traceless “Catch and Release” Solid-Phase Strategy

✍ Scribed by Ma, Wenli; Peterson, Brian; Kelson, Andrew; Laborde, Edgardo


Book ID
121318671
Publisher
American Chemical Society
Year
2009
Tongue
English
Weight
389 KB
Volume
11
Category
Article
ISSN
1520-4766

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A small molecular library of 40 pyrimidine, pyrazole, and isoxazole derivatives, bearing structural features for a promising binding of therapeutically interesting enzymes, was designed and prepared. An efficient and straightforward solid phase synthesis was envisaged and carried out on a Rink amide