A “Catch and Release” Strategy for the Parallel Synthesis of 2,4,5-Trisubstituted Pyrimidines
✍ Scribed by Porcheddu, Andrea; Giacomelli, Giampaolo; De Luca, Lidia; Ruda, Antonio Maria
- Book ID
- 126056881
- Publisher
- American Chemical Society
- Year
- 2004
- Tongue
- English
- Weight
- 109 KB
- Volume
- 6
- Category
- Article
- ISSN
- 1520-4766
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Two-dimensional libraries of 4-acylamino-1,3-thiazoles 9 were prepared via Curtius rearrangement of 1,3-thiazole-4carbonyl azides 6, trapping of the intermediate isocyanates with oxime resin, and thermal regeneration of the isocyanates from the washed resin in the presence of nucleophiles. Several c
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