Solid phase synthesis of a molecular library of pyrimidines, pyrazoles, and isoxazoles with biological potential

✍ Scribed by Giovanni Pellegrino; Francesco Leonetti; Angelo Carotti; Orazio Nicolotti; Leonardo Pisani; Angela Stefanachi; Marco Catto

• Book ID: 104097414
• Publisher: Elsevier Science
• Year: 2010
• Tongue: French
• Weight: 270 KB
• Volume: 51
• Category: Article
• ISSN: 0040-4039
• DOI: 10.1016/j.tetlet.2010.01.089

✦ Synopsis

A small molecular library of 40 pyrimidine, pyrazole, and isoxazole derivatives, bearing structural features for a promising binding of therapeutically interesting enzymes, was designed and prepared. An efficient and straightforward solid phase synthesis was envisaged and carried out on a Rink amide resin. The assistance of microwave heating in any step reduced the reaction time, increased the reaction yields, and allowed an easy work-up and purification of the targeted compounds.