The palladium-catalyzed oxidation of hydroxy-enamines, which were obtained by the condensation of P-aminoalcohols and carbonyl compounds, proceeded to give the corresponding polysubstituted pyrroles and 4,5,6,7-tetrahydroindoles in good yields. The treatment of o-(2hydroxyethyl)aniline with the pall
Efficient Synthesis of Pyrroles and 4,5,6,7-Tetrahydroindoles via Palladium-Catalyzed Oxidation of Hydroxy-Enamines.
β Scribed by Yutaka Aoyagi; Toshihiko Mizusaki; Masahiro Shishikura; Takashi Komine; Tokuji Yoshinaga; Haruko Inaba; Akihiro Ohta; Koichi Takeya
- Book ID
- 101991693
- Publisher
- John Wiley and Sons
- Year
- 2006
- Weight
- 30 KB
- Volume
- 37
- Category
- Article
- ISSN
- 0931-7597
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β¦ Synopsis
Abstract
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We have developed a facile and efficient synthesis of new conformationally restricted butyrophenones in the indole and quinoline series via palladium-catalyzed oxidation of hydroxyenaminones, and subsequent cyclization followed by spontaneous aromatization.
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