New synthetic approaches to CNS drugs. A straightforward, efficient synthesis of tetrahydroindol-4-ones and tetrahydroquinolin-5-ones via palladium-catalyzed oxidation of hydroxyenaminones

✍ Scribed by Beatriz Pita; Christian F. Masaguer; Enrique Raviña

• Book ID: 104252133
• Publisher: Elsevier Science
• Year: 2002
• Tongue: French
• Weight: 97 KB
• Volume: 43
• Category: Article
• ISSN: 0040-4039
• DOI: 10.1016/s0040-4039(02)01901-9

✦ Synopsis

We have developed a facile and efficient synthesis of new conformationally restricted butyrophenones in the indole and quinoline series via palladium-catalyzed oxidation of hydroxyenaminones, and subsequent cyclization followed by spontaneous aromatization.