Efficient synthesis of porphyrin dimers with carbon-carbon linkages
β Scribed by Ravindra K. Pandey; Fuu-Yau Shiau; Craig J. Medforth; Thomas J. Dougherty; Kevin M. Smith
- Book ID
- 104226660
- Publisher
- Elsevier Science
- Year
- 1990
- Tongue
- French
- Weight
- 240 KB
- Volume
- 31
- Category
- Article
- ISSN
- 0040-4039
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The anti-cancer activity of dimers joined with ether, ester or carbon-carbon bonds by photodynamic therapy (PDT) was compared by using DBM2 mice transplanted with SMT/F tumors. Dimers with ether and carboncarbon linkages were found to be more effective than those linked with ester bonds. Variation o
The first syntheses of a series of regiochemically pure porphyrin dimers and trimers with ether linkages which are structurally related to Photofin@ are described. Stability of these oligomers was investigated using variable temperature proton NiUR spectroscopy, and preliminary biological results re