Comparative in vivo sensitizing efficacy of porphyrin and chlorin dimers joined with ester, ether, carbon–carbon or amide bonds
✍ Scribed by Ravindra K. Pandey; Gang Zheng; David A. Lee; Thomas J. Dougherty; Kevin M. Smith
- Book ID
- 101285056
- Publisher
- John Wiley and Sons
- Year
- 1996
- Tongue
- English
- Weight
- 472 KB
- Volume
- 9
- Category
- Article
- ISSN
- 0952-3499
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✦ Synopsis
The anti-cancer activity of dimers joined with ether, ester or carbon-carbon bonds by photodynamic therapy (PDT) was compared by using DBM2 mice transplanted with SMT/F tumors. Dimers with ether and carboncarbon linkages were found to be more effective than those linked with ester bonds. Variation of the substituents at peripheral positions made a significant difference in in vivo efficacy. Among the ether and carbon-carbon linked dimers, the divinyl analogs were found to be most effective. The preliminary in vivo results also suggest that the position(s) of the hydrophilic substituents in the molecules make a remarkable difference in photosensitizing activity. An unsymmetrical dimer with an amide linkage, obtained from 2-(l-hexyloxyethyl)-2-devinyl pyropheophorbide-a (HPPH) was found to be less effective than HPPH.