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Efficient synthesis of optically active 2-amino-2'-diphenylphosphino-1,1'-binaphthyl and its derivatives

✍ Scribed by Sumi, Kenzo; Ikariya, Takao; Noyori, Ryoji


Book ID
120185188
Publisher
NRC Research Press
Year
2000
Tongue
French
Weight
186 KB
Volume
78
Category
Article
ISSN
0008-4042

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Preparation of 2-amino-2β€²-hydroxy-1,1β€²-b
✍ Robert A. Singer; Stephen L. Buchwald πŸ“‚ Article πŸ“… 1999 πŸ› Elsevier Science 🌐 French βš– 280 KB

Palladium-catalyzed amination reactions were carried out with 2-triflato-2'-(4methoxybenzyloxy)-1,1'-binaphthyl (5) and benzophenone imine followed by hydrolysis of the imine and hydrogenolysis of the benzyl protecting group to afford 2-amino-2'-hydroxy-1,1'binaphthyl (1). Arylamines were also coupl