The Synthesis of a Multiblock Osteotropi
β
Christopher D. Hein; Xin-Ming Liu; Fu Chen; Diane M. Cullen; Dong Wang
π
Article
π
2010
π
John Wiley and Sons
π
English
β 685 KB
## Abstract The design and synthesis of a novel boneβtargeting polyrotaxane delivery system that utilizes alendronate (ALN) as targeting moiety is presented in this manuscript. For the introduction of ALN, it is first conjugated to Ξ±βcyclodextrin (Ξ±βCD) and subsequently threaded onto a short poly(e