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Efficient synthesis of Hsp90 inhibitor dimers as potential antitumor agents

✍ Scribed by Hironori Sekiguchi; Kazuhiro Muranaka; Akiko Osada; Satoshi Ichikawa; Akira Matsuda


Book ID
108072860
Publisher
Elsevier Science
Year
2010
Tongue
English
Weight
389 KB
Volume
18
Category
Article
ISSN
0968-0896

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## Abstract The 6‐substituted benzimidazo[1,2‐__c__]quinazoline 1 is a lead structure from our DNA intercalator program and is cytotoxic to the human colon cancer tumor line HT‐29 with an inhibitory concentration 50, IC~50~ of 4.00 ΞΌ__M__. In order to try and improve the limited cytotoxicity of thi