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Design and synthesis of 3′,5′-ansa-adenosines as potential Hsp90 inhibitors

✍ Scribed by Kazuhiro Muranaka; Satoshi Ichikawa; Akira Matsuda


Publisher
Elsevier Science
Year
2009
Tongue
French
Weight
803 KB
Volume
50
Category
Article
ISSN
0040-4039

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Dethiobiotin synthetase (DTBS ; E.C. 6.6.6.6), the penultimate enzyme in the biosynthesis of the essential vitamin biotin, is a new potential target for novel herbicides. Inhibitors were designed based on mechanistic and structural information. The in-vitro activities of these potential inhibitors v