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2′-O-Alkyl Derivatives and 5′-Analogues of 5-Aminoimidazole-4-carboxamide-1-β-D-ribofuranoside (AICAR) as Potential Hsp90 Inhibitors

✍ Scribed by Antonio Bracci; Giorgio Colombo; Fiamma Ronchetti; Federica Compostella

Publisher
John Wiley and Sons
Year
2009
Tongue
English
Weight
254 KB
Volume
2009
Category
Article
ISSN
1434-193X

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## Abstract The __García‐González__ reaction of D‐glucose and ethyl acetoacetate generated ethyl 5‐[(1′__S__)‐D‐erythrosyl]‐2‐methyl‐3‐furoate (**5**), which was converted to ethyl 5‐[(1′__R__)‐1′,4′‐dideoxy‐1′,4′‐imino‐D‐erythrosyl]‐2‐methyl‐3‐furoate (**3c**) and to ethyl 5‐[(1′__S__)‐1′,4′‐dideo