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Efficient synthesis of esters containing tertiary amine functionalities via active cyanomethyl ester intermediates

✍ Scribed by Camille Bouillon; Gilles Quéléver; Ling Peng

Publisher: Elsevier Science
Year: 2009
Tongue: French
Weight: 372 KB
Volume: 50
Category: Article
ISSN: 0040-4039
DOI: 10.1016/j.tetlet.2009.05.034

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✦ Synopsis

Esters containing tertiary amine functionalities were successfully synthesized under mild conditions and in good yields, using a three-step process involving the activation of acids into their corresponding cyanomethyl esters, followed by transesterification with the alcohol counterparts, and subsequent scavenging of the excess of alcohol to facilitate purification.

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