The syntheses of a-ketoC2-' 3C]glutaric acid and a-ketoC1,2-' 'Cl glutaric acid were each achieved from commercial "CH,I in 5 steps. CH,NO,, prepared in situ from "CH,I and AgNO,, was treated with magnesium methyl carbonate, followed by acidified methanol to give 0,N13CH,C0,CH3. Michael addition to
Efficient syntheses of multiply 2H- and 13C-labeled acrylic acid, glyceric acid, glycidic acid and glycerol
✍ Scribed by János Pitlik; Craig A. Townsend
- Book ID
- 102659395
- Publisher
- John Wiley and Sons
- Year
- 1997
- Tongue
- French
- Weight
- 703 KB
- Volume
- 39
- Category
- Article
- ISSN
- 0022-2135
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## Abstract A series of 5β‐cholanic acids labeled with deuterium in the A ring were prepared by exchange labeling of the corresponding ketone by column chromatography on deuterated alumina. Factors affecting yield and labeling efficiency are discussed. 5β‐Cholanic acids labeled with ^13^C in the ca