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Efficient, stereoselective total synthesis of (.+-.)-aphidicolin

✍ Scribed by Ireland, Robert E.; Godfrey, Jollie D.; Thaisrivongs, Suvit


Book ID
127212074
Publisher
American Chemical Society
Year
1981
Tongue
English
Weight
390 KB
Volume
103
Category
Article
ISSN
0002-7863

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Total synthesis of aphidicolin
✍ John E. McMurry; Alex Andrus; Gary M. Ksander; John H. Musser; Mark A. Johnson πŸ“‚ Article πŸ“… 1981 πŸ› Elsevier Science 🌐 French βš– 783 KB
Total synthesis of (.+-.)-aphidicolin
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Aphidicolin synthesis (II)β€”an expeditiou
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An expeditious and efftcient formal total synthesis of an antiviral and antitumor tetracyclic diterpene aphidicolin (1) has been achieved. An intramoleculat Heck reaction (74) and an intramolecular Diels-Aldex reaction (4+3) were utilii for the key steps of the sequence.