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Efficient stereoselective synthesis of cis,syn-hydroxyitraconazole isomers

โœ Scribed by Gerald J. Tanoury; Chris H. Senanayake; Robert Hett; Yaping Hong; Stephen A. Wald


Book ID
104258223
Publisher
Elsevier Science
Year
1997
Tongue
French
Weight
217 KB
Volume
38
Category
Article
ISSN
0040-4039

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A series of novel cis-4-substituted proline analogues were designed and synthesized. Highly stereoselective alkylations at the g-position of glutamic ester 2 were achieved, followed by reduction, mesylation, and cyclization to afford the title compounds 1 in good yields and high diastereoselectivity