## Abstract A sequential transformation based on a titanium‐mediated aldol reaction from chiral α‐__tert__‐butyldimethylsilyloxy ketones followed by reduction of the resultant aldolates with LiBH~4~ provides a straightforward access to __syn__‐1,3‐diols. These diols, containing up to three new ster
Stereoselective synthesis of syn-1,3-diols
✍ Scribed by Peter Mohr
- Publisher
- Elsevier Science
- Year
- 1991
- Tongue
- French
- Weight
- 199 KB
- Volume
- 32
- Category
- Article
- ISSN
- 0040-4039
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Chx 2 BCl-mediated syn-aldol reaction of the a-OTBS lactate-derived ketone 1 followed by in situ reduction of the resulting boron aldolate with LiBH 4 lead to complete stereoselectivity for the boronates 2 in 80-95% yields. Then, a very mild oxidative work-up of 2 (H 2 O 2 /NaOAc in THF-H 2 O) allow