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Efficient one-pot synthesis of N-ethyl amino acids

✍ Scribed by Thomas Rückle; Benoit Dubray; Francis Hubler; Manfred Mutter

Publisher
John Wiley and Sons
Year
1999
Tongue
English
Weight
54 KB
Volume
5
Category
Article
ISSN
1075-2617

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✦ Synopsis

Mono-N-ethylated h-amino acid esters are obtained in high yields using reductive amination procedures. Formation of imine is achieved by excess of acetaldehyde, followed by removal of acetaldehyde and reduction by NaBH(OAc) 3 . The elaborated one-pot synthesis allows for the efficient synthesis of side-chain protected amino acid derivatives.

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