Efficient one-pot synthesis of N-ethyl a
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Thomas RΓΌckle; Benoit Dubray; Francis Hubler; Manfred Mutter
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Article
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1999
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John Wiley and Sons
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English
β 54 KB
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Mono-N-ethylated h-amino acid esters are obtained in high yields using reductive amination procedures. Formation of imine is achieved by excess of acetaldehyde, followed by removal of acetaldehyde and reduction by NaBH(OAc) 3 . The elaborated one-pot synthesis allows for the efficient synthesis of s