## Abstract ChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 100 leading journals. To access a ChemInform Abstract of an article which was published elsewhere, please select a “Full Text” option. The original article is trackable v
Efficient Conjugation of Peptides to Oligonucleotides by “Native Ligation”
✍ Scribed by Stetsenko, Dmitry A.; Gait, Michael J.
- Book ID
- 118070967
- Publisher
- American Chemical Society
- Year
- 2000
- Tongue
- English
- Weight
- 120 KB
- Volume
- 65
- Category
- Article
- ISSN
- 0022-3263
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📜 SIMILAR VOLUMES
## Abstract Peptide–oligonucleotide conjugates have frequently been synthesized to improve cellular delivery of antisense or antigene compounds, to allow the immobilization of peptide and protein conjugates on DNA arrays, or to decorate nucleic acid architectures with peptide functions. In such app
An oligonucleotide was functionalized on the solid-phase by a tartaramide moiety, which could be converted efficiently in solution into a glyoxylyl group following a mild periodic oxidation. The glyoxylyl-oligonucleotide was found to be very stable upon storage and was successfully engaged in hydraz
A convenient solid-phase synthesis of a PNA sequence containing an N-terminal thiaproline and a C-terminal thioester is described. The usefulness of this bifunctional PNA molecule is illustrated by the construction, based on native ligation, of a peptide-PNA-peptide adduct.
## Abstract For Abstract see ChemInform Abstract in Full Text.