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An approach to the synthesis of peptide–PNA–peptide conjugates via native ligation

✍ Scribed by Martijn C de Koning; Dmitri V Filippov; Nico Meeuwenoord; Mark Overhand; Gijs A van der Marel; Jacques H van Boom

Publisher
Elsevier Science
Year
2002
Tongue
French
Weight
150 KB
Volume
43
Category
Article
ISSN
0040-4039

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✦ Synopsis

A convenient solid-phase synthesis of a PNA sequence containing an N-terminal thiaproline and a C-terminal thioester is described. The usefulness of this bifunctional PNA molecule is illustrated by the construction, based on native ligation, of a peptide-PNA-peptide adduct.

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Native chemical ligation in the synthesis of internally modified oligonucleotide–peptide conjugates
✍ Franziska Diezmann; Hendrik Eberhard; Oliver Seitz 📂 Article 📅 2010 🏛 Wiley (John Wiley & Sons) 🌐 English ⚖ 248 KB 👁 2 views

## Abstract Peptide–oligonucleotide conjugates have frequently been synthesized to improve cellular delivery of antisense or antigene compounds, to allow the immobilization of peptide and protein conjugates on DNA arrays, or to decorate nucleic acid architectures with peptide functions. In such app