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Efficient and scalable synthesis of thiazole fused benzazepine as a D2 partial agonist

โœ Scribed by Xiong, Hui; Wu, Ye; Lehr, Scott G.; Blackwell, William; Steelman, Gary; Hulsizer, Jim; Urbanek, Rebecca A.


Book ID
121479983
Publisher
Elsevier Science
Year
2012
Tongue
French
Weight
507 KB
Volume
53
Category
Article
ISSN
0040-4039

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A novel selective and partial agonist S21007 (IC% =InM), for 5HT3 receptor studies in positron emission tomography, has been labelled with ("Cjbenzyl iodide in 40-50% radiochemical yield and 200-700mCilpmol in 60 min synthesis time.