✦ LIBER ✦

Efficient and Scalable Synthesis of Ethyl 2,6-Dichloro-5-Fluoronicotinoyl Acetate Using the Blaise Reaction as a Key Step 1

✍ Scribed by Choi, Bo Seung; Chang, Jay Hyok; Choi, Hyeong-wook; Kim, Young Keun; Lee, Ki Kon; Lee, Kyu Woong; Lee, Jae Hoon; Heo, Taeho; Nam, Do Hyun; Shin, Hyunik

Book ID: 126964186
Publisher: American Chemical Society
Year: 2005
Tongue: English
Weight: 177 KB
Volume: 9
Category: Article
ISSN: 1083-6160
DOI: 10.1021/op050012a

No coin nor oath required. For personal study only.

📜 SIMILAR VOLUMES

Discovery of the Decarboxylative Blaise

Discovery of the Decarboxylative Blaise Reaction and Its Application to the Efficient Synthesis of Ethyl 2,6-Dichloro-5-fluoronicotinoylacetate(1)

✍ Lee, Jae Hoon; Choi, Bo Seung; Chang, Jay Hyok; Kim, Sam Sik; Shin, Hyunik 📂 Article 📅 2007 🏛 American Chemical Society 🌐 English ⚖ 82 KB

An efficient synthesis of carbon-14-labe

An efficient synthesis of carbon-14-labeled 6-[2-(dimethylamino)ethyl]-14-(1-ethylpropyl)-5,6,7,8-tetrahydroindolo [2,1-α] [2,5]benzodiazocine-11-carboxylic acid using Curtius rearrangement reaction as a key step

✍ Andy Shiqiang Zhang; Jonathan Z. Ho; Matthew P. Braun 📂 Article 📅 2010 🏛 John Wiley and Sons 🌐 French ⚖ 219 KB 👁 1 views

## Abstract Here we report an efficient synthesis of ^14^C‐labeled 6‐[2‐(dimethylamino)ethyl]‐14‐(1‐ethylpropyl)‐5,6,7,8‐tetrahydroindolo‐[2,1‐__α__][2,5]benzodiazocine‐11‐carboxylic acid (1) using the Curtius rearrangement as a key step. The synthesis was initiated by converting the unlabeled aryl

Selective Hydrolysis of Ethyl 5,6-Dihydr

Selective Hydrolysis of Ethyl 5,6-Dihydro-4H-pyrrolo[1,2- b ]pyrazole-2-carboxylate and Ethyl 5,6-Dihydro-4H-pyrrolo[1,2- b ]pyrazole-3-carboxylate as a Key Step in the Large-Scale Synthesis of Bicyclic Heteroaryl Carboxyaldehydes

✍ Nikitenko, A. A.; Winkley, M. W.; Zeldis, J.; Kremer, K.; Chan, A. W.-Y.; Strong 📂 Article 📅 2006 🏛 American Chemical Society 🌐 English ⚖ 76 KB

ChemInform Abstract: Synthesis of 3,7-An

ChemInform Abstract: Synthesis of 3,7-Anhydro-D-glycero-D-ido-octitol 1,5,6-Trisphosphate as an IP3 Receptor Ligand Using a Radical Cyclization Reaction with a Vinylsilyl Tether as the Key Step. Conformational Restriction Strategy Using Steric Repulsion Between Adjacent Bulky Protecting Groups on a Pyranose Ring.

✍ Satoshi Shuto; Yumi Yahiro; Satoshi Ichikawa; Akira Matsuda 📂 Article 📅 2000 🏛 John Wiley and Sons ⚖ 42 KB 👁 1 views

Synthesis of 3,7-Anhydro- d - g lycero -

Synthesis of 3,7-Anhydro- d - g lycero - d - i do -octitol 1,5,6-Trisphosphate as an IP 3 Receptor Ligand Using a Radical Cyclization Reaction with a Vinylsilyl Tether as the Key Step. Conformational Restriction Strategy Using Steric Repulsion between Adjacent Bulky Protecting Groups on a Pyranose Ring

✍ Shuto, Satoshi; Yahiro, Yumi; Ichikawa, Satoshi; Matsuda, Akira 📂 Article 📅 2000 🏛 American Chemical Society 🌐 English ⚖ 165 KB

Design and Synthesis of [2-(8,9-Dioxo-2,

Design and Synthesis of [2-(8,9-Dioxo-2,6-diazabicyclo[5.2.0]non-1(7)-en-2-yl)- ethyl]phosphonic Acid (EAA-090), a Potent N -Methyl- d -aspartate Antagonist, via the Use of 3-Cyclobutene-1,2-dione as an Achiral α-Amino Acid Bioisostere

✍ Kinney, William A.; Abou-Gharbia, Magid; Garrison, Deanna T.; Schmid, Jean; Kowa 📂 Article 📅 1998 🏛 American Chemical Society 🌐 English ⚖ 348 KB