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Efficient and practical synthesis of optically active 5-t-butyldimethylsiloxy-2-cyclohexenone as a convenient chiral 2,5-cyclohexadienone synthon

✍ Scribed by Shinichi Hikichi; Georges P-J. Hareau; Fumie Sato


Publisher
Elsevier Science
Year
1997
Tongue
French
Weight
208 KB
Volume
38
Category
Article
ISSN
0040-4039

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Optically active trans-4-(tert-butyldime
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Optically active trans-4-(tert-butyldimethylsiloxymethyl)-5-(tert-butyldimethylsiloxy)-2-cyclohexenone (2) has been synthesized in 25% overall yield starting from easily available 1,4-bis(benzyloxy)-2,3-epoxy butane (3). The enone 2 reacts with excellent stereoselectivity with RCu(CN)Li thus working

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