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Optically active trans-4-(tert-butyldimethylsiloxymethyl)-5-(tert-butyldimethylsiloxy)-2-cyclohexenone as a useful chiral building block for preparation of substituted cyclohexane rings: synthesis and its highly stereoselective reaction with RCu(CN)Li

✍ Scribed by Takeshi Hanazawa; Masakazu Koiwa; Georges P.-J. Hareau; Fumie Sato

Publisher
Elsevier Science
Year
2000
Tongue
French
Weight
116 KB
Volume
41
Category
Article
ISSN
0040-4039

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✦ Synopsis

Optically active trans-4-(tert-butyldimethylsiloxymethyl)-5-(tert-butyldimethylsiloxy)-2-cyclohexenone (2) has been synthesized in 25% overall yield starting from easily available 1,4-bis(benzyloxy)-2,3-epoxy butane (3). The enone 2 reacts with excellent stereoselectivity with RCu(CN)Li thus working as an efficient chiral building block for preparation of substituted cyclohexane compounds.

πŸ“œ SIMILAR VOLUMES

ChemInform Abstract: Optically Active tr
ChemInform Abstract: Optically Active trans-4-(tert-Butyldimethylsiloxymethyl)-5- (tert-butyldimethylsiloxy)-2-cyclohexenone as a Useful Chiral Building Block for Preparation of Substituted Cyclohexane Rings: Synthesis and Its Highly Stereoselective Reaction with RCu(CN)Li.
✍ Takeshi Hanazawa; Masakazu Koiwa; Georges P.-J. Hareau; Fumie Sato πŸ“‚ Article πŸ“… 2010 πŸ› John Wiley and Sons βš– 33 KB πŸ‘ 1 views

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