Efficient and practical asymmetric synthesis of 1-tert-butyl 3-methyl (3R,4R)-4-(2-oxo-2,3-dihydro-1H-benzimidazol-1-yl)piperidine-1,3-dicarboxylate, a useful intermediate for the synthesis of nociceptin antagonists
โ Scribed by Hideki Jona; Jun Shibata; Masanori Asai; Yasuhiro Goto; Sachie Arai; Shigeru Nakajima; Osamu Okamoto; Hiroshi Kawamoto; Yoshikazu Iwasawa
- Book ID
- 108284503
- Publisher
- Elsevier Science
- Year
- 2009
- Tongue
- English
- Weight
- 662 KB
- Volume
- 20
- Category
- Article
- ISSN
- 0957-4166
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## Abstract magnified image Oneโpot reaction of 3โarylโ5โmethylโ1,3,4โoxadiazolinโ2โones **1aโg** with ethanolamine yielded the 4โ(2โhydroxyethyl)โ2โarylโ5โmethylโ2,4โdihydroโ3__H__โ1,2,4โtriazolinโ3โones **2aโg** which were converted to the azido compounds **6aโg**. These azides on 1,3โdipolar cy
A Practical Synthesis of 3-[(1R)-1-t-Butyldimethylsilyloxyethyl]-4-[(2R)-4-halo-3-oxo-2-butyl]azetidinone, a Versatile Intermediate for Carbapenem Antibiotics. -The readily available carboxylic acid (I) is converted efficiently by a three-step procedure into the title compounds such as (VI). Desily