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Efficacy of Reirradiation for Patients With Recurrent High-grade Glioma

✍ Scribed by Tsutsumi, Y.; Harada, H.; Hirasawa, N.; Ogawa, H.; Asakura, H.; Fuji, H.; Murayama, S.; Mitsuya, K.; Nakasu, Y.; Nishimura, T.

Book ID
122403883
Publisher
Elsevier Science
Year
2012
Tongue
English
Weight
54 KB
Volume
84
Category
Article
ISSN
0360-3016

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## Abstract ## BACKGROUND Doxorubicin exhibits high efficacy in malignant glioma cell cultures. Nonetheless, as a standard formulation, doxorubicin has not been used clinically, due to poor penetration of the blood‐brain barrier. Furthermore, doxorubicin is known to induce tumor resistance genes.