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Efficacy of protracted dose-dense temozolomide in patients with recurrent high-grade glioma

✍ Scribed by Ufuk Abacioglu; Hale B. Caglar; Perran F. Yumuk; Zuleyha Akgun; Beste M. Atasoy; Meric Sengoz

Publisher
Springer US
Year
2010
Tongue
English
Weight
266 KB
Volume
103
Category
Article
ISSN
0167-594X

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## Abstract ## BACKGROUND Doxorubicin exhibits high efficacy in malignant glioma cell cultures. Nonetheless, as a standard formulation, doxorubicin has not been used clinically, due to poor penetration of the blood‐brain barrier. Furthermore, doxorubicin is known to induce tumor resistance genes.