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Efficacy and safety of hydroxyurea in patients with essential thrombocythemia

✍ Scribed by G Finazzi; T Barbui

Book ID
117507710
Publisher
Elsevier Science
Year
2001
Tongue
English
Weight
34 KB
Volume
49
Category
Article
ISSN
0369-8114

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Essential thrombocythemia (El) Is an uncommon myeloprollferatlve disorder, which is thought to develop from a multlpotent stem cell. Like other myeloprollferatlve diseases, ET is assoclated with an increased risk of development of acute leukemla (AL). However, the large majority of cases of leukemic

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Leukemogenic risk of hydroxyurea therapy in polycythemia vera, essential thrombocythemia, and myeloid metaplasia with myelofibrosis
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In polycythemia Vera (PV), treatment with chlorambucil and radioactive phosphorus (p32) increases the risk of leukemic transformation from 1% to 13-14%. This risk has been estimated to be 1-5.9% with hydroxyurea (HU) therapy. When compared with historical controls, the risk with use of HU does not a