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Acute myeloid leukemia evolving from essential thrombocythemia in two patients treated with hydroxyurea

✍ Scribed by Furgerson, James L.; Vukelja, Svetislava J.; Baker, W. Jeffrey; O'Rourke, Timothy J.

Publisher
John Wiley and Sons
Year
1996
Tongue
English
Weight
372 KB
Volume
51
Category
Article
ISSN
0361-8609

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✦ Synopsis

Essential thrombocythemia (El) Is an uncommon myeloprollferatlve disorder, which is thought to develop from a multlpotent stem cell. Like other myeloprollferatlve diseases, ET is assoclated with an increased risk of development of acute leukemla (AL). However, the large majority of cases of leukemic transformation in ET are thought to be related to prior therapy, usually radioactive phosphorous or alkylatlng chemotherapy, and the development of AL In ET Is extremely rare In the untreated patient. in this report, two cases of ET which evolved into AL without prior exposure to radiation or alkylatlng agents, and which were treated with long-term hydroxyurea therapy, are described. The first case had cytogenetlc changes In the bone marrow suggestive of therapy-associated leukemia, and the second developed myelodysplastic syndrome on therapy which was llkely chemotherapy-Induced and led to acute leukemia. Prolonged used of hydroxyurea In patients with ET may lead to therapy-associated acute leukemia.

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