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Efficacy and Safety of Donepezil in Patients with Alzheimer’s Disease

✍ Scribed by Mercè Boada-Rovira, Henry Brodaty, Patrick Cras, Stavros Baloyannis…


Book ID
120807242
Publisher
Springer International Publishing AG
Year
2004
Tongue
English
Weight
149 KB
Volume
21
Category
Article
ISSN
1170-229X

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## Abstract ## Objective This 132‐week, open‐label extension study assessed the long‐term efficacy and safety of donepezil in 579 patients with mild to moderate Alzheimer's disease (AD) who had previously participated in a 24‐week double‐blind study of 5 or 10 mg/day donepezil __vs__ placebo. ##

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## Abstract ## Background There have been very limited investigations of cholinesterase inhibitor therapy in more advanced stages of Alzheimer's disease (AD). The efficacy and safety of donepezil were evaluated in __post hoc__ analyses of a subgroup of patients with more severe AD (standardized Mi