Efficacy and safety of donepezil in patients with Alzheimer's disease: preliminary findings from the Australian subset of a global clinical experience study
β Scribed by H. Brodaty; R. Bahra; R. Zhang; M. O'Leary; K. Short; M. Barrington
- Book ID
- 119574932
- Publisher
- Elsevier Science
- Year
- 2000
- Tongue
- English
- Weight
- 112 KB
- Volume
- 10
- Category
- Article
- ISSN
- 0924-977X
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## Abstract ## Objective This 132βweek, openβlabel extension study assessed the longβterm efficacy and safety of donepezil in 579 patients with mild to moderate Alzheimer's disease (AD) who had previously participated in a 24βweek doubleβblind study of 5 or 10βmg/day donepezil __vs__ placebo. ##
## Abstract ## Background There have been very limited investigations of cholinesterase inhibitor therapy in more advanced stages of Alzheimer's disease (AD). The efficacy and safety of donepezil were evaluated in __post hoc__ analyses of a subgroup of patients with more severe AD (standardized Mi