Efficacious cleavage of the benzyl ether protecting group by electrochemical oxidation
β Scribed by Weinreb, Steven M.; Epling, Gary A.; Comi, Richard; Reitano, Michael
- Book ID
- 126136903
- Publisher
- American Chemical Society
- Year
- 1975
- Tongue
- English
- Weight
- 450 KB
- Volume
- 40
- Category
- Article
- ISSN
- 0022-3263
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## Abstract ChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 100 leading journals. To access a ChemInform Abstract of an article which was published elsewhere, please select a βFull Textβ option. The original article is trackable v
The oxidation of aikoxyaUylic ethers by PCC produces the corresponding Β’z,[J-unsaturated ketones or aldehydes and the oxidation of benzylic alcohols produces the corresponding ketones in satLrfltctory yields.
The selective cleavage of the PMB (4-methoxybenzyl) group in the presence of the NAP (2-naphthylmethyl) group was achieved using CAN with a range of mono-saccharides. The NAP group can then be removed selectively in the presence of a benzyl group using DDQ. This provides a strategy for sequential de