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Sequential removal of the benzyl-type protecting groups PMB and NAP by oxidative cleavage using CAN and DDQ

โœ Scribed by Joseph A Wright; Jinquan Yu; Jonathan B Spencer

Publisher
Elsevier Science
Year
2001
Tongue
French
Weight
65 KB
Volume
42
Category
Article
ISSN
0040-4039

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โœฆ Synopsis

The selective cleavage of the PMB (4-methoxybenzyl) group in the presence of the NAP (2-naphthylmethyl) group was achieved using CAN with a range of mono-saccharides. The NAP group can then be removed selectively in the presence of a benzyl group using DDQ. This provides a strategy for sequential deprotection of hydroxyl groups.

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Enzymatic removal of acyl protecting gro
Enzymatic removal of acyl protecting groups. The use of dihydrocinnamoyl group in oligonucleotide synthesis and its cleavage by ฮฑ-chymotrypsin
โœ H.S. Sachdev; N.A. Starkovsky ๐Ÿ“‚ Article ๐Ÿ“… 1969 ๐Ÿ› Elsevier Science ๐ŸŒ French โš– 204 KB

One of the major problems,in oligonucleotide synthesis is the design of suitable protecting groups for the reactive hydroxyl and amino functions of nucleosides and nucleotides. Ideally, these protecting groups should satisfy the following conditions: 1) they should be stable under the reaction cond