Effects of zonisamide on extracellular levels of monoamine and its metabolite, and on Ca2+ ependent dopamine release

✍ Scribed by M Okada; S Kaneko; T Hirano; M Ishida; T Kondo; K Otani; Y Fukushima

• Publisher: Elsevier Science
• Year: 1992
• Tongue: English
• Weight: 672 KB
• Volume: 13
• Category: Article
• ISSN: 0920-1211
• DOI: 10.1016/0920-1211(92)90066-3

✦ Synopsis

The effects of zonisamide (3-sulfamoylmethyl-1,2-benzisoxazole), a novel anticonvulsant, on extracellular levels of monoamine and its metabolite in the striatum and hippocampus, and Ca2+ dependent monoamine release in the striatum of freely moving rats were studied by microdialysis. Zonisamide increased dopamine, homovanillic acid and 5-hydroxyindoleacetic acid, and decreased 3,4-dihydroxyphenylacetic acid in the rat striatum. However, zonisamide showed no effect on Ca2+ dependent dopamine release in the rat striatum. In the hippocampus, zonisamide increased dopamine, homovanillic acid, serotonin and 5-hydroxyindoleacetic acid and decreased 3,4-dihydroxyphenylacetic acid. The present results suggest that zonisamide facilitates dopaminergic and serotoninergic neurotransmission but does not affect Ca2+ dependent dopamine release within therapeutic plasma concentrations.