The technique of in vivo microdialysis was used to measure the extracellular levels of dopamine in the nucleus accumbens septi and medial prefrontal cortex of chloral-hydrate-anaesthetized rats following systemic administration of cocaine and amphetamine. Intravenous injection of cocaine increased t
Effects of cocaine on extracellular dopamine and serotonin levels in the nucleus accumbens
โ Scribed by Christine M. Andrews; Irwin Lucki
- Publisher
- Springer
- Year
- 2001
- Tongue
- English
- Weight
- 158 KB
- Volume
- 155
- Category
- Article
- ISSN
- 0033-3158
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Combined administration of the amphetamine analogs phentermine and fenfluramine (PHEN/FEN) has been used in the treatment of obesity. While these medications are thought to modulate monoamine transmission, the precise neurochemical effects of the PHEN/FEN mixture have not been extensively studied. T
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Rats were treated for 10 days with cocaine (20 mgkg, i.p.1 followed by either 1 or 10 days of abstinence. On the test day a microdialysis method was performed in which dopamine (DA) was added to the perfusate at concentrations above and below the expected extracellular concentration (0,2.5, 5, and 1