The effect of carbidopa on plasma and mu
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S. Rose; P. Jenner; Prof. C. D. Marsden
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Article
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1988
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John Wiley and Sons
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English
β 518 KB
Administration of L-dopa (L-3,4-dihydroxyphenylalanine) (200 mg/kg p.o.) to rats produced elevated plasma and muscle concentrations of both L-dopa and 3-O-methyldopa (3-OMD). This effect was potentiated by simultaneous administration of carbidopa (25 mg/kg p.o.). Both L-dopa and 3-OMD accumulated in