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Effect of subchronic administration of tolcapone on L-DOPA-and carbidopa-induced release of striatal dopamine and its metabolites

✍ Scribed by E. A. Budygin; R. R. Gainetdinov; K. S. Raevskii; P. T. Mannisto


Publisher
Springer US
Year
1998
Tongue
English
Weight
247 KB
Volume
125
Category
Article
ISSN
0007-4888

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✍ S. Rose; P. Jenner; Prof. C. D. Marsden πŸ“‚ Article πŸ“… 1988 πŸ› John Wiley and Sons 🌐 English βš– 518 KB

Administration of L-dopa (L-3,4-dihydroxyphenylalanine) (200 mg/kg p.o.) to rats produced elevated plasma and muscle concentrations of both L-dopa and 3-O-methyldopa (3-OMD). This effect was potentiated by simultaneous administration of carbidopa (25 mg/kg p.o.). Both L-dopa and 3-OMD accumulated in